A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence

A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence

Abstract Background Macromoleculization of nitroxides has been an effective strategy to improve low relaxivities and poor in vivo stability, however, nitroxides-based metal-free magnetic resonance imaging (MRI) macromolecular contrast agents (mCAs) are still under-performed. These mCAs do not posses...

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Bibliographic Details
Main Authors: Shiwei Guo, Xiaoming Wang, Zhiqian Li, Dayi Pan, Yan Dai, Yun Ye, Xiaohe Tian, Zhongwei Gu, Qiyong Gong, Hu Zhang, Kui Luo
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Nanobiotechnology
Subjects:
Nitroxides-based contrast agents
Longitudinal relaxivity
Magnetic resonance imaging
Cancer diagnosis
Nanomedicines
Polymeric carriers
Online Access:https://doi.org/10.1186/s12951-021-00990-6

Internet

https://doi.org/10.1186/s12951-021-00990-6

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