Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis

Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis

Imatinib mesylate is a tyrosine kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR)-α, -β, stem cell factor receptor (c-KIT), and BCR-ABL. PDGFRα is expressed in a subset of interstitial cells in the lamina propria (LP) and detrusor muscle of the urinary bladder. PDGFRα +...

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Bibliographic Details
Main Authors: Megan Perkins, Beatrice M. Girard, Susan E. Campbell, Grant W. Hennig, Margaret A. Vizzard
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Systems Neuroscience
Subjects:
painful bladder syndrome
interstitial cells
platelet-derived growth factor receptor (PDGFR)
cytokines
cell signaling
lamina propria
Online Access:https://www.frontiersin.org/articles/10.3389/fnsys.2022.884260/full

Internet

https://www.frontiersin.org/articles/10.3389/fnsys.2022.884260/full

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