Uncovering emergent phenotypes in endothelial cells by clustering of surrogates of cardiovascular risk factors

Abstract Endothelial dysfunction (ED) is a hallmark of atherosclerosis and is influenced by well-defined risk factors, including hypoxia, dyslipidemia, inflammation, and oscillatory flow. However, the individual and combined contributions to the molecular underpinnings of ED remain elusive. We used...

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Bibliographic Details
Main Authors: Iguaracy Pinheiro-de-Sousa, Miriam H. Fonseca-Alaniz, Samantha K. Teixeira, Mariliza V. Rodrigues, Jose E. Krieger
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05404-7