The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a process known as inside-out activation. We previous...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-11-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4230843?pdf=render |