A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Human pluripotent stem cell (hPSC)-derived neural cultures have attracted interest for modeling epilepsy and seizure-like activity in vitro. Clinical and experimental evidence have shown that the multifunctional inflammatory cytokine interleukin (IL)-6 plays a significant role in epilepsy. However,...

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Bibliographic Details
Main Authors: Ropafadzo Mzezewa, Johanna Lotila, Heikki Kiiski, Andrey Vinogradov, Fikret Emre Kapucu, Jukka Peltola, Sanna Hagman, Susanna Narkilahti
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Stem Cell Research
Subjects:
Cortical neurons
Disease modeling
Interleukin 6
Human pluripotent stem cells
Microelectrode arrays
Seizures
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122000149

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http://www.sciencedirect.com/science/article/pii/S1873506122000149

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