Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells

Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells

Signal regulatory protein-α (SIRPα, SHPS-1, CD172a) expressed on myeloid cells transmits inhibitory signals when it engages its counter-receptor CD47 on an adjacent cell. Elevated CD47 expression on some cancer cells thereby serves as an innate immune checkpoint that limits phagocytic clearance of t...

Full description

Bibliographic Details
Main Authors: Sukhbir Kaur, Bianca Reginauld, Sam Razjooyan, Trung Phi, Satya P. Singh, Thomas J. Meyer, Margaret C. Cam, David D. Roberts
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD47
SIRPα
EMT
cancer stem cells
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1356421/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1356421/full

Similar Items