NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling

NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling

NOTCH4 is a member of the NOTCH family of receptors whose expression is intensively induced in macrophages after their activation by Toll-like receptors (TLR) and/or interferon-γ (IFN-γ). In this work, we show that this receptor acts as a negative regulator of macrophage activation by diminishing th...

Full description

Bibliographic Details
Main Authors: Susana López-López, María José Romero de Ávila, Natalia Carolina Hernández de León, Francisco Ruiz-Marcos, Victoriano Baladrón, María Luisa Nueda, Jorge Laborda, José Javier García-Ramírez, Eva M. Monsalve, María José M. Díaz-Guerra
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
macrophage
inflammation
NOTCH4
IFN-γ
TLR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.734966/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.734966/full

Similar Items