Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues

Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues

The presentation of virus-derived peptides by HLA class I molecules on the surface of an infected cell and the recognition of these HLA-peptide complexes by, and subsequent activation of, CD8+ cytotoxic T cells provides an important mechanism for immune protection against viruses. Recent advances in...

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Bibliographic Details
Main Authors: Mayank Srivastava, Richard Copin, Augustine Choy, Anbo Zhou, Olav Olsen, Sarah Wolf, Darshit Shah, Anna Rye-Weller, Lisa Chen, Newton Chan, Angel Coppola, Kathryn Lanza, Nicole Negron, Min Ni, Gurinder S. Atwal, Christos A. Kyratsous, William Olson, Robert Salzler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
proteogenomics
Hepatitis B
hepatocellular carcinoma
immunopeptidomics
human leukocyte antigen (HLA)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032716/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032716/full

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