Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism.

Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism.

Most cancer cells exhibit a shift in glucose metabolic strategy, displaying increased glycolysis even with adequate oxygen supply. SUMO-specific proteases (SENPs) de-SUMOylate substrates including HIF1α and p53,two key regulators in cancer glucose metabolism, to regulate their activity, stability an...

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Bibliographic Details
Main Authors: Shuang Tang, Gang Huang, Xuemei Tong, Lian Xu, Rong Cai, Jie Li, Xiang Zhou, Shaoli Song, Chen Huang, Jinke Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3653847?pdf=render

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http://europepmc.org/articles/PMC3653847?pdf=render

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