The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic neuropathic pain in mice

The upregulation of NLRP3 inflammasome in dorsal root ganglion by ten-eleven translocation methylcytosine dioxygenase 2 (TET2) contributed to diabetic neuropathic pain in mice

Abstract Background The nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity in multiple neuropathic pain models, but the function of the NLRP3 in diabetic neuropathic pain (DNP) and the regu...

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Bibliographic Details
Main Authors: Wen Chen, Xiaotong Wang, Qingyu Sun, Yurui Zhang, Jing Liu, Tingting Hu, Weihua Wu, Chao Wei, Meng Liu, Yumeng Ding, Dianxin Liu, Yingzi Chong, Peipei Wang, Hongwei Zhu, Weihua Cui, Jiannan Zhang, Qian Li, Fei Yang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Diabetic neuropathic pain
TET2
NLRP3 inflammasome
Dorsal root ganglion
Online Access:https://doi.org/10.1186/s12974-022-02669-7

Internet

https://doi.org/10.1186/s12974-022-02669-7

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