New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies

New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies

Two series of cyanopyrimidine hybrids were synthesized bearing either benzo[<i>d</i>]imidazole, benzo[<i>d</i>]oxazole, benzo[<i>d</i>]thiazole, and benzo[<i>b</i>]thiophene derivatives via methylene amino linker <b>3a</b>–<b>3d</b...

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Bibliographic Details
Main Authors: Hanan A. AL-Ghulikah, Samiha A. El-Sebaey, Amr K. A. Bass, Mona S. El-Zoghbi
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
COX-2 inhibitiors
cyanopyrimidine
anticancer
benzoazoles
benzenesulphonamides
Online Access:https://www.mdpi.com/1420-3049/27/21/7485

Internet

https://www.mdpi.com/1420-3049/27/21/7485

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