Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

AbstractThe present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarit...

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Bibliographic Details
Main Authors: Ibrahim M. Salem, Samia M. Mostafa, Ismail Salama, Osama I. El-Sabbagh, Wael A. H. Hegazy, Tarek S. Ibrahim
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Pyrazolo[34-d]pyrimidine
N-acyl amino acids
methotrexate
DHFR inhibition
MCF-7 breast cancer cell line
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2142786

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2142786

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