DEEPCYPs: A deep learning platform for enhanced cytochrome P450 activity prediction

Cytochrome P450 (CYP) is a superfamily of heme-containing oxidizing enzymes involved in the metabolism of a wide range of medicines, xenobiotics, and endogenous compounds. Five of the CYPs (1A2, 2C9, 2C19, 2D6, and 3A4) are responsible for metabolizing the vast majority of approved drugs. Adverse dr...

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Bibliographic Details
Main Authors: Daiqiao Ai, Hanxuan Cai, Jiajia Wei, Duancheng Zhao, Yihao Chen, Ling Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1099093/full