Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism

Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism

Abstract Background Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, the effects of gut microbiota and short-chain fatty acids (SCFAs), as important metabolic products, on intestinal function and potential...

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Bibliographic Details
Main Authors: Shao-Hua Su, Yi-Fang Wu, Qi Lin, Lin Zhang, Da-Peng Wang, Jian Hai
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Chronic cerebral hypoperfusion
Gut microbiota
short-chain fatty acids
Mitochondrial energy metabolism
Treg/Th17 balance
Online Access:https://doi.org/10.1186/s12974-022-02675-9

Internet

https://doi.org/10.1186/s12974-022-02675-9

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