Anisodamine (654-1/654-2) ameliorates septic kidney injury in rats by inhibiting inflammation and apoptosis

Anisodamine (654-1/654-2) ameliorates septic kidney injury in rats by inhibiting inflammation and apoptosis

IntroductionTo investigate the protective effects of anisodamine (654-1/654-2) against acute kidney injury (AKI) in LPS-induced septic shock rats and explore its molecular mechanisms.Methods56 rats were randomly divided into 8 groups: control, LPS, LPS + 654-1, and LPS + 654-2 (1.25, 2.5 and 5 mg/kg...

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Bibliographic Details
Main Authors: Dong Liu, Fei Tang, Li Zhang, Feng Wan, Li-Yue Xu, Jing-Nan Zhang, Xiao-Lan Zhao, Hui Ao, Cheng Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
septic shock
anisodamine (654-1/654-2)
acute kidney injury
apoptosis
inflammatory
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1421551/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1421551/full

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