Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions

Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions

Abstract Synthetic biology has allowed for the industrial production of supply-limited sesquiterpenoids such as the antimalarial drug artemisinin and β-farnesene. One of the only unmodified animal products used in medicine is squalene, a triterpenoid derived from shark liver oil, which when formulat...

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Bibliographic Details
Main Authors: Karl J. Fisher, Robert Kinsey, Raodoh Mohamath, Tony Phan, Hong Liang, Mark T. Orr, William R. Lykins, Jeffrey A. Guderian, Julie Bakken, David Argilla, Gabi Ramer-Denisoff, Elise Larson, Yizhi Qi, Sandra Sivananthan, Karina Smolyar, Darrick Carter, Christopher J. Paddon, Christopher B. Fox
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00608-y

Internet

https://doi.org/10.1038/s41541-023-00608-y

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