Aptamer–Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells

Aptamer–Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells

Gemcitabine is a chemotherapeutic used clinically to treat a variety of cancers. However, because it lacks tumor cell specificity, gemcitabine may cause off-target cytotoxicity and adversely impact patients. To impart cancer cell specificity to gemcitabine and improve its therapeutic efficacy, we sy...

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Bibliographic Details
Main Authors: Jianjun Qi, Zihua Zeng, Zhenghu Chen, Cole Nipper, Xiaohui Liu, Quanyuan Wan, Jian Chen, Ching-Hsuan Tung, Youli Zu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
aptamer–drug conjugates
enzymatically cleavable linker
controlled intracellular drug release
high gemcitabine payload
targeted drug delivery
cell-specific chemotherapy
Online Access:https://www.mdpi.com/1424-8247/15/5/558

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https://www.mdpi.com/1424-8247/15/5/558

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