Design, Synthesis and Biological Evaluation of Novel Anthraniloyl-AMP Mimics as PQS Biosynthesis Inhibitors Against <i>Pseudomonas aeruginosa</i> Resistance

Design, Synthesis and Biological Evaluation of Novel Anthraniloyl-AMP Mimics as PQS Biosynthesis Inhibitors Against <i>Pseudomonas aeruginosa</i> Resistance

The <i>Pseudomonas</i> quinolone system (PQS) is one of the three major interconnected quorum sensing signaling systems in <i>Pseudomonas aeruginosa</i>. The virulence factors PQS and HHQ activate the transcription regulator PqsR (MvfR), which controls several activities in b...

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Bibliographic Details
Main Authors: Shekh Sabir, Sujatha Subramoni, Theerthankar Das, David StC. Black, Scott A. Rice, Naresh Kumar
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
<i>Pseudomonas</i> quinolone system
quorum sensing
<i>Pseudomonas aeruginosa</i>
virulence factors
biofilm
anthraniloyl-AMP mimics
Online Access:https://www.mdpi.com/1420-3049/25/13/3103

Internet

https://www.mdpi.com/1420-3049/25/13/3103

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