Randomized clinical trial comparing intravitreal aflibercept combined with subthreshold laser to intravitreal aflibercept monotherapy for diabetic macular edema

Abstract To compare the efficacy and safety of intravitreal aflibercept with three loading doses + pro re nata regimen combined with subthreshold laser application to that of IVA monotherapy on eyes with diabetic macular edema. This was a phase 4 clinical trial with a prospective, randomized, and pa...

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Bibliographic Details
Main Authors: Tomoaki Tatsumi, Yoko Takatsuna, Toshiyuki Oshitari, Tomomi Kaiho, Yohei Kawasaki, Yuki Shiko, Takeshi Sugawara, Takayuki Baba, Shuichi Yamamoto
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14444-y