Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes
Abstract Background Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of disproportionate subunits. To determine how human cells coordinate mitochondrial and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-022-02732-9 |