Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

αD-conotoxins are 11 kDa homodimers that potently inhibit nicotinic acetylcholine receptors (nAChRs) through a non-competitive (allosteric) mechanism. In this study, we describe the allosteric binding mode of the granulin-like C-terminal (CTD) of VxXXB bound to Lymnea stagnalis acetylcholine binding...

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Bibliographic Details
Main Authors: Thao NT Ho, Nikita Abraham, Richard J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
α-conotoxin
α7 nAChR
pharmacology
AChBP
allosteric
granulin fold
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1170514/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1170514/full

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