Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease
Excess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress is a well-established cause of organ damage in the liver, the main site of iron storage. Ferroptosis, an iron-dependent mechanism of regulated cell death, has rec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/13/2/208 |
| _version_ | 1827344246021029888 |
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| author | Sophie Gensluckner Bernhard Wernly Christian Datz Elmar Aigner |
| author_facet | Sophie Gensluckner Bernhard Wernly Christian Datz Elmar Aigner |
| author_sort | Sophie Gensluckner |
| collection | DOAJ |
| description | Excess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress is a well-established cause of organ damage in the liver, the main site of iron storage. Ferroptosis, an iron-dependent mechanism of regulated cell death, has recently been gaining attention in the development of organ damage and the progression of liver disease. We therefore summarize the main mechanisms of iron metabolism, its close connection to oxidative stress and ferroptosis, and its particular relevance to disease mechanisms in metabolic-dysfunction-associated fatty liver disease and potential targets for therapy from a clinical perspective. |
| first_indexed | 2024-03-07T22:44:16Z |
| format | Article |
| id | doaj.art-1bc0cc5f63c24be6a4704c15354a89bf |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-07T22:44:16Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1bc0cc5f63c24be6a4704c15354a89bf2024-02-23T15:05:30ZengMDPI AGAntioxidants2076-39212024-02-0113220810.3390/antiox13020208Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver DiseaseSophie Gensluckner0Bernhard Wernly1Christian Datz2Elmar Aigner3Department of Internal Medicine I, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, AustriaDepartment of Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, 5110 Oberndorf, AustriaDepartment of Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, 5110 Oberndorf, AustriaDepartment of Internal Medicine I, Paracelsus Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, AustriaExcess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress is a well-established cause of organ damage in the liver, the main site of iron storage. Ferroptosis, an iron-dependent mechanism of regulated cell death, has recently been gaining attention in the development of organ damage and the progression of liver disease. We therefore summarize the main mechanisms of iron metabolism, its close connection to oxidative stress and ferroptosis, and its particular relevance to disease mechanisms in metabolic-dysfunction-associated fatty liver disease and potential targets for therapy from a clinical perspective.https://www.mdpi.com/2076-3921/13/2/208iron metabolismoxidative stressferroptosisMASLDliver fibrosis |
| spellingShingle | Sophie Gensluckner Bernhard Wernly Christian Datz Elmar Aigner Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease Antioxidants iron metabolism oxidative stress ferroptosis MASLD liver fibrosis |
| title | Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease |
| title_full | Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease |
| title_fullStr | Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease |
| title_full_unstemmed | Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease |
| title_short | Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease |
| title_sort | iron oxidative stress and metabolic dysfunction associated steatotic liver disease |
| topic | iron metabolism oxidative stress ferroptosis MASLD liver fibrosis |
| url | https://www.mdpi.com/2076-3921/13/2/208 |
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