RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific

RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific

Abstract Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs). The vast majority of ucRBPs have uncharacterized RNA-binding specificities. We analyzed 492...

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Bibliographic Details
Main Authors: Debashish Ray, Kaitlin U. Laverty, Arttu Jolma, Kate Nie, Reuben Samson, Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk, Syed Nabeel-Shah, Mihai Albu, Hong Zheng, Gabrielle Perron, Hyunmin Lee, Hamed Najafabadi, Benjamin Blencowe, Jack Greenblatt, Quaid Morris, Timothy R. Hughes
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-32245-9

Internet

https://doi.org/10.1038/s41598-023-32245-9

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