Design and Preclinical Evaluation of Nicotine–Stearic Acid Conjugate-Loaded Solid Lipid Nanoparticles for Transdermal Delivery: A Technical Note

Design and Preclinical Evaluation of Nicotine–Stearic Acid Conjugate-Loaded Solid Lipid Nanoparticles for Transdermal Delivery: A Technical Note

This study aimed to develop and evaluate nicotine--stearic acid conjugate-loaded solid lipid nanoparticles (NSA-SLNs) for transdermal delivery in nicotine replacement therapy (NRT). Nicotine conjugation to stearic acid prior to SLN formulation greatly increased drug loading. SLNs loaded with a nicot...

Full description

Bibliographic Details
Main Authors: Jwala Renukuntla, Samuel Peterson-Sockwell, Bradley A. Clark, Nipunika H. Godage, Emanuela Gionfriddo, Pradeep Kumar Bolla, Sai H. S. Boddu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
nicotine
stearic acid
solid lipid nanoparticles
gel
transdermal permeation
smoking cessation
Online Access:https://www.mdpi.com/1999-4923/15/4/1043

Internet

https://www.mdpi.com/1999-4923/15/4/1043

Similar Items