Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation

Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation

Since westernized diet-induced insulin resistance is a risk factor in Alzheimer’s disease (AD) development, and lipopolysaccharide (LPS) coexists with amyloid β (Aβ)1-42 in these patients, our AD novel model was developed to resemble sporadic AD by injecting LPS into high fat/fructose diet (HFFD)-fe...

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Bibliographic Details
Main Authors: Reem A. Mohamed, Dalaal M. Abdallah, Amany I. El-brairy, Kawkab A. Ahmed, Hanan S. El-Abhar
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
5-HT3 receptor blocker
inflammasome
pyroptosis
caspase-1/IL-1β/IL-18
microglia
α7AChR
Online Access:https://www.mdpi.com/1420-3049/26/16/5068

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https://www.mdpi.com/1420-3049/26/16/5068

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