Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation

Curcumin-Piperlongumine Hybrids with a Multitarget Profile Elicit Neuroprotection in In Vitro Models of Oxidative Stress and Hyperphosphorylation

Curcumin shows a broad spectrum of activities of relevance in the treatment of Alzheimer’s disease (AD); however, it is poorly absorbed and is also chemically and metabolically unstable, leading to a very low oral bioavailability. A small library of hybrid compounds designed as curcumin analogues an...

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Bibliographic Details
Main Authors: Ángel Cores, Noelia Carmona-Zafra, Olmo Martín-Cámara, Juan Domingo Sánchez, Pablo Duarte, Mercedes Villacampa, Paloma Bermejo-Bescós, Sagrario Martín-Aragón, Rafael León, J. Carlos Menéndez
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
oxidative stress
Tau aggregation
neuroinflammation
neuroprotection
Online Access:https://www.mdpi.com/2076-3921/11/1/28

Internet

https://www.mdpi.com/2076-3921/11/1/28

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