Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary differential equation (ODE)-based model as a...

Full description

Bibliographic Details
Main Authors: Radu Mihaila, Dipali Ruhela, Edward Keough, Elena Cherkaev, Silvia Chang, Beverly Galinski, René Bartz, Duncan Brown, Bonnie Howell, James J. Cunningham
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA interference
siRNA
lipid nanoparticles
mathematical modeling
intracellular trafficking
cellular pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301531

Internet

http://www.sciencedirect.com/science/article/pii/S2162253117301531

Similar Items