Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology

Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein (α-syn) is the major component of Lewy bodies in PD patients...

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Bibliographic Details
Main Authors: Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Qi Zhu, HuanXing Su, Min Li, JiaoYan Ren, Jie-Qiong Tan, Jia-Hong Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
canthin-6-one
Parkinson’s disease
alpha-synuclein
ubiquitin-proteasome-system
CRISPR/Cas9
RPN2/PSMD1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00016/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00016/full

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