Costs of ribosomal RNA stabilization affect ribosome composition at maximum growth rate
Abstract Ribosomes are key to cellular self-fabrication and limit growth rate. While most enzymes are proteins, ribosomes consist of 1/3 protein and 2/3 ribonucleic acid (RNA) (in E. coli). Here, we develop a mechanistic model of a self-fabricating cell, validated across diverse growth conditions. T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-05815-4 |