X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

The SARS-CoV-2 protease Mpro is essential for viral replication. Here, the authors have determined the structures of Mpro in complex with 10 of the 11 viral cleavage sequences including a covalent acyl-enzyme intermediate, providing mechanistic and structural insights for antiviral development.

Bibliographic Details
Main Authors: Jaeyong Lee, Calem Kenward, Liam J. Worrall, Marija Vuckovic, Francesco Gentile, Anh-Tien Ton, Myles Ng, Artem Cherkasov, Natalie C. J. Strynadka, Mark Paetzel
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32854-4

Internet

https://doi.org/10.1038/s41467-022-32854-4

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