Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice

Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice

Abstract Background Elderly patients suffering from osteoporotic fractures are more susceptible to delayed union or nonunion, and their bodies then are in a state of low-grade chronic inflammation with decreased antioxidant capacity. Tanshinone IIA is widely used in treating cardiovascular and cereb...

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Bibliographic Details
Main Authors: Shao Cheng, Xiaohui Hu, Kanghui Sun, Ziyu Huang, Yongjian Zhao, Yueli Sun, Bo Zeng, Jing Wang, Dongfeng Zhao, Sheng Lu, Qi Shi, Yongjun Wang, Weian Zhang, Xinhua Liu, Bing Shu
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Tanshinone IIA
Osteoporotic fracture
Injectable hydrogel
Mesenchymal stem cell
Oxidative stress
Cell apoptosis
Online Access:https://doi.org/10.1186/s13018-024-04793-x

Internet

https://doi.org/10.1186/s13018-024-04793-x

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