Uric Acid Mediated the Association Between BMI and Postmenopausal Breast Cancer Incidence: A Bidirectional Mendelian Randomization Analysis and Prospective Cohort Study

Uric Acid Mediated the Association Between BMI and Postmenopausal Breast Cancer Incidence: A Bidirectional Mendelian Randomization Analysis and Prospective Cohort Study

BackgroundObservational epidemiological studies have reported the associations of high body mass index (BMI) with elevated serum uric acid (UA) level and increased risk of postmenopausal breast cancer. However, whether UA is causally induced by BMI and functioned in the BMI–breast cancer relationshi...

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Bibliographic Details
Main Authors: Yue Feng, Ming Fu, Xin Guan, Chenming Wang, Fangfang Yuan, Yansen Bai, Hua Meng, Guyanan Li, Wei Wei, Hang Li, Mengying Li, Jiali Jie, Yanjun Lu, Huan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Endocrinology
Subjects:
postmenopausal breast cancer
body mass index
uric acid
Mendelian randomization analysis
cohort study
mediation analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.742411/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.742411/full

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