MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon exposure to a microbial product and respond m...

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Bibliographic Details
Main Authors: Allison M. Owen, Liming Luan, Katherine R. Burelbach, Margaret A. McBride, Cody L. Stothers, Olivia A. Boykin, Kalkena Sivanesam, Jessica F. Schaedel, Tazeen K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. Patil, Edward R. Sherwood, Julia K. Bohannon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor (TLR)
TLR4
innate immunity
trained immunity
macrophage
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044662/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044662/full

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