DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations

DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations

Accurate computational identification of B-cell epitopes is crucial for the development of vaccines, therapies, and diagnostic tools. However, current structure-based prediction methods face limitations due to the dependency on experimentally solved structures. Here, we introduce DiscoTope-3.0, a ma...

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Bibliographic Details
Main Authors: Magnus Haraldson Høie, Frederik Steensgaard Gade, Julie Maria Johansen, Charlotte Würtzen, Ole Winther, Morten Nielsen, Paolo Marcatili
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
structure-based
B cell epitope prediction
inverse-folding
antibody epitope prediction
ESM-IF1
immunogenicity prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322712/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322712/full

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