Rescue of the Congenital Hereditary Endothelial Dystrophy Mouse Model by Adeno-Associated Virus–Mediated Slc4a11 Replacement

Rescue of the Congenital Hereditary Endothelial Dystrophy Mouse Model by Adeno-Associated Virus–Mediated Slc4a11 Replacement

Purpose: Congenital hereditary endothelial dystrophy (CHED) is a rare condition that manifests at an early age showing corneal edema, increased oxidative stress, mitochondrial dysfunction, and eventually apoptosis of the endothelium due to loss of function of the membrane transport protein SLC4A11....

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Bibliographic Details
Main Authors: Rajalekshmy Shyam, PhD, Diego G. Ogando, PhD, Edward T. Kim, BS, Subashree Murugan, BOptom, Moonjung Choi, PhD, Joseph A. Bonanno, OD, PhD
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Ophthalmology Science
Subjects:
Adeno-associated virus
Congenital hereditary endothelial dystrophy
Endothelial dystrophy
Gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914521000865

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http://www.sciencedirect.com/science/article/pii/S2666914521000865

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