PIK3CA mutations in endocrine-resistant breast cancer

Abstract Around 75% of breast cancer (BC) patients have tumors expressing the predictive biomarker estrogen receptor α (ER) and are offered endocrine therapy. One-third eventually develop endocrine resistance, a majority with retained ER expression. Mutations in the phosphatidylinositol bisphosphate...

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Bibliographic Details
Main Authors: Caroline Schagerholm, Stephanie Robertson, Hosein Toosi, Emmanouil G. Sifakis, Johan Hartman
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-62664-1