NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

It is unclear whether arterial specification is required for hematopoietic stem cell formation. Here, the authors use a chemically defined human pluripotent stem cell (hPSC) differentiation system to show the role of NOTCH signaling in forming arterial-type hemogenic endothelial cells.

Bibliographic Details
Main Authors: Gene I. Uenishi, Ho Sun Jung, Akhilesh Kumar, Mi Ae Park, Brandon K. Hadland, Ethan McLeod, Matthew Raymond, Oleg Moskvin, Catherine E. Zimmerman, Derek J. Theisen, Scott Swanson, Owen J. Tamplin, Leonard I. Zon, James A. Thomson, Irwin D. Bernstein, Igor I. Slukvin
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04134-7

Internet

https://doi.org/10.1038/s41467-018-04134-7

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