LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1 to regulate the translation of 5’TOP mRNAs such as those encoding ribosome proteins (RP). However, the roles of LARP1 in the translation of 5’TOP mRNAs are controversial and its regulatory roles in mTORC1-mediated tra...

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Bibliographic Details
Main Authors: Sungki Hong, Mallory A Freeberg, Ting Han, Avani Kamath, Yao Yao, Tomoko Fukuda, Tsukasa Suzuki, John K Kim, Ken Inoki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-06-01
Series:eLife
Subjects:
La-related protein 1
mTORC1
translation
Akt
ribosome biogenesis
S6K1
Online Access:https://elifesciences.org/articles/25237

Internet

https://elifesciences.org/articles/25237

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