Levodopa responsive freezing of gait is associated with reduced norepinephrine transporter binding in Parkinson's disease

Levodopa responsive freezing of gait is associated with reduced norepinephrine transporter binding in Parkinson's disease

Background: Freezing of gait (FOG) is a major cause of falling in Parkinson's disease (PD) and can be responsive or unresponsive to levodopa. Pathophysiology is poorly understood. Objective: To examine the link between noradrenergic systems, the development of FOG in PD and its responsiveness t...

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Bibliographic Details
Main Authors: J. Lucas McKay, Jonathan Nye, Felicia C. Goldstein, Barbara Sommerfeld, Yoland Smith, David Weinshenker, Stewart A. Factor
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Freezing of gait
Norepinephrine transporter
Positron emission tomography
Norepinephrine
Primary progressive freezing of gait
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000621

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http://www.sciencedirect.com/science/article/pii/S0969996123000621

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