The effects of MYC on tumor immunity and immunotherapy
Abstract The oncogene MYC is dysregulated in a host of human cancers, and as an important point of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in tumor immune regulation in the tumor immune microenvironment (TIME). Specifically, MYC promotes the expression of i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01403-3 |
| _version_ | 1827979561216770048 |
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| author | Jiajin Li Tingyu Dong Zhen Wu Dacheng Zhu Hao Gu |
| author_facet | Jiajin Li Tingyu Dong Zhen Wu Dacheng Zhu Hao Gu |
| author_sort | Jiajin Li |
| collection | DOAJ |
| description | Abstract The oncogene MYC is dysregulated in a host of human cancers, and as an important point of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in tumor immune regulation in the tumor immune microenvironment (TIME). Specifically, MYC promotes the expression of immunosuppressive factors and inhibits the expression of immune activation regulators. Undoubtedly, a therapeutic strategy that targets MYC can initiate a new era of cancer treatment. In this review, we summarize the essential role of the MYC signaling pathway in tumor immunity and the development status of MYC-related therapies, including therapeutic strategies targeting MYC and combined MYC-based immunotherapy. These studies have reported extraordinary insights into the translational application of MYC in cancer treatment and are conducive to the emergence of more effective immunotherapies for cancer. |
| first_indexed | 2024-04-09T21:38:40Z |
| format | Article |
| id | doaj.art-1be5b563b94748a48f6741045e1ec8d4 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-04-09T21:38:40Z |
| publishDate | 2023-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-1be5b563b94748a48f6741045e1ec8d42023-03-26T11:06:42ZengNature Publishing GroupCell Death Discovery2058-77162023-03-019111010.1038/s41420-023-01403-3The effects of MYC on tumor immunity and immunotherapyJiajin Li0Tingyu Dong1Zhen Wu2Dacheng Zhu3Hao Gu4Department of Pediatrics, Second Clinical School of Medicine, Anhui Medical UniversityDepartment of Pediatrics, Second Clinical School of Medicine, Anhui Medical UniversityDepartment of Clinical Medicine, First Clinical School of Medicine, Anhui Medical UniversityDepartment of Clinical Medicine, First Clinical School of Medicine, Anhui Medical UniversityDepartment of Immunology, School of Basic Medical Sciences, Anhui Medical UniversityAbstract The oncogene MYC is dysregulated in a host of human cancers, and as an important point of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in tumor immune regulation in the tumor immune microenvironment (TIME). Specifically, MYC promotes the expression of immunosuppressive factors and inhibits the expression of immune activation regulators. Undoubtedly, a therapeutic strategy that targets MYC can initiate a new era of cancer treatment. In this review, we summarize the essential role of the MYC signaling pathway in tumor immunity and the development status of MYC-related therapies, including therapeutic strategies targeting MYC and combined MYC-based immunotherapy. These studies have reported extraordinary insights into the translational application of MYC in cancer treatment and are conducive to the emergence of more effective immunotherapies for cancer.https://doi.org/10.1038/s41420-023-01403-3 |
| spellingShingle | Jiajin Li Tingyu Dong Zhen Wu Dacheng Zhu Hao Gu The effects of MYC on tumor immunity and immunotherapy Cell Death Discovery |
| title | The effects of MYC on tumor immunity and immunotherapy |
| title_full | The effects of MYC on tumor immunity and immunotherapy |
| title_fullStr | The effects of MYC on tumor immunity and immunotherapy |
| title_full_unstemmed | The effects of MYC on tumor immunity and immunotherapy |
| title_short | The effects of MYC on tumor immunity and immunotherapy |
| title_sort | effects of myc on tumor immunity and immunotherapy |
| url | https://doi.org/10.1038/s41420-023-01403-3 |
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