Effect of Previous Alkylating Agent Exposure on Follicle Numbers in Cryopreserved Prepubertal and Young Adult Ovarian Tissue after Long-Term Xenografting

Effect of Previous Alkylating Agent Exposure on Follicle Numbers in Cryopreserved Prepubertal and Young Adult Ovarian Tissue after Long-Term Xenografting

Purpose and methods: To elucidate whether previous cancer treatment affects graft recovery and follicle numbers, morphology, and development in grafts, cryopreserved ovarian biopsies obtained from 18 cancer patients aged 1–24 years with and without exposure to chemotherapy were xenografted as 1 mm&l...

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Bibliographic Details
Main Authors: Mirja Nurmio, Babak Asadi-Azarbaijani, Mi Hou, Ronja Kiviö, Jorma Toppari, Helena Tinkanen, Tiina Laine, Irma C. Oskam, Kirsi Jahnukainen
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
fertility preservation
children and young adults
alkylating agents
xenografting
ovarian follicles
Online Access:https://www.mdpi.com/2072-6694/14/2/399

Internet

https://www.mdpi.com/2072-6694/14/2/399

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