Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

The α-ketoglutarate–dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues. Although PHD3 has been reported to influence cancer cell metabolism and liver insulin sensitivity, relatively little is known about the effec...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson
Format: Artykuł
Język:English
Wydane: American Society for Clinical investigation 2021-08-01
Seria:JCI Insight
Hasła przedmiotowe:
Endocrinology
Metabolism
Dostęp online:https://doi.org/10.1172/jci.insight.140288

Internet

https://doi.org/10.1172/jci.insight.140288

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