HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites

Human cytomegalovirus (HCMV) infection and periodic reactivation is, generally, well controlled by adaptative immune responses in the healthy. In older people, overt HCMV disease is rarely seen despite the association of HCMV with increased risk of mortality; evidence from studies of unwell aged pop...

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Bibliographic Details
Main Authors: Emma L. Davies, Mahlaqua Noor, Eleanor Y. Lim, Charlotte J. Houldcroft, Georgina Okecha, Claire Atkinson, Matthew B. Reeves, Sarah E. Jackson, Mark R. Wills
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus (HCMV)
immune senescence
anti-viral T cells
aging
neutralizing antibodies
anti-viral assays
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1083230/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1083230/full

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