Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate the small molecule induction of human iPSC-derived cardiomyocyte proliferation

Multi-omic analysis reveals VEGFR2, PI3K, and JNK mediate the small molecule induction of human iPSC-derived cardiomyocyte proliferation

Summary: Mammalian hearts lose their regenerative potential shortly after birth. Stimulating the proliferation of preexisting cardiomyocytes is a potential therapeutic strategy for cardiac damage. In a previous study, we identified 30 compounds that induced the bona-fide proliferation of human iPSC-...

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Bibliographic Details
Main Authors: Laura A. Woo, Kaitlyn L. Wintruba, Bethany Wissmann, Svyatoslav Tkachenko, Ewa Kubicka, Emily Farber, Ola Engkvist, Ian Barrett, Kenneth L. Granberg, Alleyn T. Plowright, Matthew J. Wolf, David L. Brautigan, Stefan Bekiranov, Qing-Dong Wang, Jeffrey J. Saucerman
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:iScience
Subjects:
Biopharmaceuticals
Molecular biology
Proteomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224017103

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http://www.sciencedirect.com/science/article/pii/S2589004224017103

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