The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer

The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer

The MEK-ERK growth signaling pathway is important in human hepatocellular carcinoma (HCC). To evaluate the targeting of this pathway in HCC, we characterized a novel, orally-active MEK inhibitor, PD184161, using human HCC cells (HepG2, Hep3B, PLC, and SKHep) and in vivo human tumor xenografts. PD184...

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Bibliographic Details
Main Authors: Patrick J. Klein, C. Max Schmidt, Chad A. Wiesenauer, Jennifer N. Choi, Earl A. Gage, Michele T. Yip-Schneider, Eric A. Wiebke, Yufang Wang, Charles Omer, Judith S. Sebolt-Leopold
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Hepatocellular carcinoma
liver cancer
MEK
ERK
PD184161
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800357

Internet

http://www.sciencedirect.com/science/article/pii/S1476558606800357

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