An integrated toolkit for human microglia functional genomics

An integrated toolkit for human microglia functional genomics

Summary Background Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such...

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Bibliographic Details
Main Authors: Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah, Falak Sher
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Stem Cell Research & Therapy
Subjects:
Neurodegenerative diseases
Microglia
iPSC-derived microglia (iMG)
Functional genomics
CRISPR
Chromatin accessibility (ATAC-Seq)
Online Access:https://doi.org/10.1186/s13287-024-03700-9

Internet

https://doi.org/10.1186/s13287-024-03700-9

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