Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

Abstract Neutral antagonists of GPCRs remain relatively rare—indeed, a large majority of GPCR antagonists are actually inverse agonists. The synthetic cannabinoid receptor agonist (SCRA) EG‐018 was recently reported as a low efficacy cannabinoid receptor agonist. Here we report a comparative charact...

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Bibliographic Details
Main Authors: David B. Finlay, Thuy Nguyen, Thomas F. Gamage, Shuli Chen, Daniel G. Barrus, Purvi R. Patel, Brian F. Thomas, Jenny L. Wiley, Yanan Zhang, Michelle Glass
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Pharmacology Research & Perspectives
Subjects:
cannabinoids
CB1 receptor
EG‐018
signal transduction
structure‐activity relationships
Online Access:https://doi.org/10.1002/prp2.901

Internet

https://doi.org/10.1002/prp2.901

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