The importance of preexisting drug resistance due to overexpression of P-glycoprotein for the formation of resistance to bortezomib
Objective of the study. In our work we investigated the effect of pre-existing drug resistance by the mechanism of activation of ABC transporters – P-glycoprotein (Pgp) overexpression – on the development of resistance to the proteasome inhibitor bortezomib.Materials and methods. Cultures RPMI8226 a...
Main Authors: | , , |
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Format: | Article |
Language: | Russian |
Published: |
ABV-press
2020-03-01
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Series: | Успехи молекулярной онкологии |
Subjects: | |
Online Access: | https://umo.abvpress.ru/jour/article/view/254 |