The importance of preexisting drug resistance due to overexpression of P-glycoprotein for the formation of resistance to bortezomib

Objective of the study. In our work we investigated the effect of pre-existing drug resistance by the mechanism of activation of ABC transporters – P-glycoprotein (Pgp) overexpression – on the development of resistance to the proteasome inhibitor bortezomib.Materials and methods. Cultures RPMI8226 a...

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Bibliographic Details
Main Authors: L. A. Laletina, N. I. Moiseeva, A. F. Karamysheva
Format: Article
Language:Russian
Published: ABV-press 2020-03-01
Series:Успехи молекулярной онкологии
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Online Access:https://umo.abvpress.ru/jour/article/view/254