Lithium inhibits tumorigenic potential of PDA cells through targeting hedgehog-GLI signaling pathway.

Lithium inhibits tumorigenic potential of PDA cells through targeting hedgehog-GLI signaling pathway.

Hedgehog signaling pathway plays a critical role in the initiation and development of pancreatic ductal adenocarcinoma (PDA) and represents an attractive target for PDA treatment. Lithium, a clinical mood stabilizer for mental disorders, potently inhibits the activity of glycogen synthase kinase 3β...

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Bibliographic Details
Main Authors: Zhonglu Peng, Zhengyu Ji, Fang Mei, Meiling Lu, Yu Ou, Xiaodong Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3634073?pdf=render

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http://europepmc.org/articles/PMC3634073?pdf=render

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