Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements
Citrus bioflavonoids are polyphenolic plant-derived pigments found in high levels in oranges, lemons, grapefruits and other citrus fruits. The three most abundant types of citrus bioflavonoids are hesperidin, naringenin and eriocitrin. Citrus bioflavonoids have long been known to possess powerful fr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4741 |
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| author | Ankit Gupta Hayder A. Al-Aubaidy Christian K. Narkowicz Herbert F. Jelinek David S. Nichols John R. Burgess Glenn A. Jacobson |
| author_facet | Ankit Gupta Hayder A. Al-Aubaidy Christian K. Narkowicz Herbert F. Jelinek David S. Nichols John R. Burgess Glenn A. Jacobson |
| author_sort | Ankit Gupta |
| collection | DOAJ |
| description | Citrus bioflavonoids are polyphenolic plant-derived pigments found in high levels in oranges, lemons, grapefruits and other citrus fruits. The three most abundant types of citrus bioflavonoids are hesperidin, naringenin and eriocitrin. Citrus bioflavonoids have long been known to possess powerful free radical-scavenging properties and cardioprotective effects. The study involved the analysis of 10 commercially available citrus bioflavonoid supplements from three different countries: Australia, the United States and Canada. The supplements were tested for their citrus bioflavonoid content which varied from 0.8 to 33.3% <i>w</i>/<i>w</i>. The daily bioflavonoid dose varied from 19 mg to 560 mg. Hesperidin was the major citrus bioflavonoid in nine out of ten supplements. One supplement was found to contain less than 10% of the quantity of rutin claimed to have been added. The DPP-4 inhibitory potential, compared through an estimation of rutin equivalence, ranged from 1.9 mg to 400 mg per day. This data highlights the variability between the supplements in their potential to inhibit DPP-4 for subsequent health benefits. |
| first_indexed | 2024-03-09T05:10:45Z |
| format | Article |
| id | doaj.art-1c1414d765794474a2895b78a6c86ef4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:10:45Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1c1414d765794474a2895b78a6c86ef42023-12-03T12:49:22ZengMDPI AGMolecules1420-30492022-07-012715474110.3390/molecules27154741Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available SupplementsAnkit Gupta0Hayder A. Al-Aubaidy1Christian K. Narkowicz2Herbert F. Jelinek3David S. Nichols4John R. Burgess5Glenn A. Jacobson6School of Medicine, University of Tasmania, Hobart, TAS 7000, AustraliaSchool of Medicine, University of Tasmania, Hobart, TAS 7000, AustraliaSchool of Medicine, University of Tasmania, Hobart, TAS 7000, AustraliaDepartment of Biomedical Engineering and Health Engineering Innovation Center, Khalifa University, Abu Dhabi 127788, United Arab EmiratesCentral Science Laboratory, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Medicine, University of Tasmania, Hobart, TAS 7000, AustraliaSchool of Medicine, University of Tasmania, Hobart, TAS 7000, AustraliaCitrus bioflavonoids are polyphenolic plant-derived pigments found in high levels in oranges, lemons, grapefruits and other citrus fruits. The three most abundant types of citrus bioflavonoids are hesperidin, naringenin and eriocitrin. Citrus bioflavonoids have long been known to possess powerful free radical-scavenging properties and cardioprotective effects. The study involved the analysis of 10 commercially available citrus bioflavonoid supplements from three different countries: Australia, the United States and Canada. The supplements were tested for their citrus bioflavonoid content which varied from 0.8 to 33.3% <i>w</i>/<i>w</i>. The daily bioflavonoid dose varied from 19 mg to 560 mg. Hesperidin was the major citrus bioflavonoid in nine out of ten supplements. One supplement was found to contain less than 10% of the quantity of rutin claimed to have been added. The DPP-4 inhibitory potential, compared through an estimation of rutin equivalence, ranged from 1.9 mg to 400 mg per day. This data highlights the variability between the supplements in their potential to inhibit DPP-4 for subsequent health benefits.https://www.mdpi.com/1420-3049/27/15/4741bioflavonoidcitrusdipeptidyl peptidase-4 (DPP-4)rutinsupplementsflavonoids |
| spellingShingle | Ankit Gupta Hayder A. Al-Aubaidy Christian K. Narkowicz Herbert F. Jelinek David S. Nichols John R. Burgess Glenn A. Jacobson Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements Molecules bioflavonoid citrus dipeptidyl peptidase-4 (DPP-4) rutin supplements flavonoids |
| title | Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements |
| title_full | Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements |
| title_fullStr | Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements |
| title_full_unstemmed | Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements |
| title_short | Analysis of Citrus Bioflavonoid Content and Dipeptidyl Peptidase-4 Inhibitory Potential of Commercially Available Supplements |
| title_sort | analysis of citrus bioflavonoid content and dipeptidyl peptidase 4 inhibitory potential of commercially available supplements |
| topic | bioflavonoid citrus dipeptidyl peptidase-4 (DPP-4) rutin supplements flavonoids |
| url | https://www.mdpi.com/1420-3049/27/15/4741 |
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